CalcuSyn 丨 混合药物分析软件



CalcuSyn 2.0版是组合药物效应的权威分析仪,能够自动量化协同作用和抑制等现象。混合药物治疗在癌症,艾滋病等的治疗中变得越来越普遍,而CalcuSyn用于在该领域建立疗效的普遍使用的软件。它使用TC Chou和P.Talaly(Trends Pharmacol.Sci.4,450-454)描述中位效应方法进行多种药物剂量效应计算。



CalcuSyn 2.0版具有撤销和重做工具。可灵活安排打印结果和图表,并将其导出到电子表格,文字处理程序,图形软件包等。一本综合手册以软件形式提供.pdf,并有详细的帮助文件。这些分析方法的理论基础,包括结果的统计处理。CalcuSyn已经在数百家学术实验室和制药公司中使用,对于药物混合物的研究是必要的。


CalcuSyn Version 2.0 is the definitive analyzer of combined drug effects, able automatically to quantify phenomena such as synergism and inhibition. Mixed drug treatment is becoming common in the treatment of cancer, AIDS etc, and CalcuSyn is the most widely used software for establishing efficacy in this field. It performs multiple drug dose-effect calculations using the Median Effect methods described by T-C Chou and P. Talalay (Trends Pharmacol. Sci. 4, 450-454).

CalcuSyn can easily be integrated with other software. Data can be entered via the keyboard or file import either into the grid or directly into the analysis engine. When the grid is used, data can be processed through wizards which make the software easily accessible to new users.

Data can be processed both for individual drugs and for constant-ratio or non-constant-ratio combinations of drugs. CalcuSyn automatically graphs the data and produces reports giving summary statistics on all drugs plus detailed analysis of drug interactions including the Combination Index and EDx (for any value of x). Estimates of accuracy of EDx and CI can be calculated with Monte Carlo simulations or by a highly accurate algebraic estimation algorithm. The plots drawn by CalcuSyn include dose-effect, median-effect, isobolograms and CI-effect. All data and results are easily accessible by mouse-click on the contents tree.

CalcuSyn Version 2.0 has Undo and Redo tools. There are flexible arrangements for printing of results and graphs and their export to spreadsheets, wordprocessors, graphics packages etc. A comprehensive manual is supplied as .pdf with the software and there is a detailed Help file. These give a thorough account of the theoretical basis of the analysis methods including the statistical treatment of results. Already used in hundreds of academic labs and pharmaceutical companies, CalcuSyn is indispensable for the study of drug mixtures.

General Science Range(普通的科学范围)

FigSys- Publication quality graph plotting and data analysis.

Stat-200- General statistics and graphics package.

UnGraph- Digitizer program which gives X,Y coordinates of lines or points on scanned


Biomedical Range(生物医学范围)

AssayZap- Universal assay calculator for RIA, ELISA, IRMA, colorimetric or any other type

of assay.

CalcuSyn- Dose-effect analysis.

EnzFitter- Curve fitting and analysis of enzyme kinetics experiments.

QuantiScan- Densitometry using ordinary office scanners.

Educational / Teaching Range(教育/教学范围)

NeuroSim- Neurophysiology simulations.

CardioLab- Simulation of in vivo cardiovascular pharmacology experiments.

Ileum- Simulation of experiments on the isolated Guinea-pig Ileum.


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